In Vivo Evaluation of TNF-Alpha in the Lungs of Patients Affected by Sarcoidosis
Joint Authors
Galli, Filippo
Ricci, Alberto
Lanzolla, Tiziana
Pietrangeli, Vittorio
Malviya, Gaurav
Bruno, Pierdonato
Ragni, Paola
Scopinaro, Francesco
Mariotta, Salvatore
Signore, Alberto
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Sarcoidosis is a multisystemic granulomatous disorder characterized by multiple noncaseating granulomas involving intrathoracic lymph nodes and lung parenchyma.
Recently, the use of anti-tumor necrosis factor alpha (anti-TNFα) agents has been introduced for therapy of chronic and refractory sarcoidosis with controversial results.
Infliximab (Remicade) is a chimeric monoclonal antibody (mAb) that recognizes and binds TNFα, neutralizing its biological effects.
In the present study, Tc 99m labelled infliximab was used to study the expression of TNFα in sarcoid lesions and to evaluate its role as a predictive marker in response to therapy with Remicade.
Material and Methods.
A total of 10 patients with newly diagnosed sarcoidosis were enrolled together with 10 control patients affected by rheumatoid arthritis.
All patients were studied by planar imaging of the chest with Tc 99m-infliximab at 6 h and 24 h and total body [18F]-FDG PET/CT.
Regions of interest were drawn over the lungs and the right arm and target-to-background ratios were analysed for Tc 99m-infliximab.
SUVmean and SUVmax were calculated over lungs for FDG.
Results and Discussion.
Image analysis showed low correlation between T/B ratios and BAL results in patients despite positivity at [18F]-FDG PET.
Conclusion.
In conclusion, patients with newly diagnosed pulmonary sarcoidosis, with FDG-PET and BAL positivity, showed a negative Tc 99m-infliximab scintigraphy.
American Psychological Association (APA)
Galli, Filippo& Lanzolla, Tiziana& Pietrangeli, Vittorio& Malviya, Gaurav& Ricci, Alberto& Bruno, Pierdonato…[et al.]. 2015. In Vivo Evaluation of TNF-Alpha in the Lungs of Patients Affected by Sarcoidosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055333
Modern Language Association (MLA)
Galli, Filippo…[et al.]. In Vivo Evaluation of TNF-Alpha in the Lungs of Patients Affected by Sarcoidosis. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055333
American Medical Association (AMA)
Galli, Filippo& Lanzolla, Tiziana& Pietrangeli, Vittorio& Malviya, Gaurav& Ricci, Alberto& Bruno, Pierdonato…[et al.]. In Vivo Evaluation of TNF-Alpha in the Lungs of Patients Affected by Sarcoidosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055333