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Circulating S100B and Adiponectin in Children Who Underwent Open Heart Surgery and Cardiopulmonary Bypass
Joint Authors
Li Volti, Giovanni
Varrica, Alessandro
Satriano, Angela
Giamberti, Alessandro
Tettamanti, Guido
Anastasia, Luigi
Conforti, Erika
Gavilanes, Antonio D. W.
Zimmermann, Luc J.
Vles, Hans J. S.
Gazzolo, Diego
Frigiola, Alessandro
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
S100B protein, previously proposed as a consolidated marker of brain damage in congenital heart disease (CHD) newborns who underwent cardiac surgery and cardiopulmonary bypass (CPB), has been progressively abandoned due to S100B CNS extra-source such as adipose tissue.
The present study investigated CHD newborns, if adipose tissue contributes significantly to S100B serum levels.
Methods.
We conducted a prospective study in 26 CHD infants, without preexisting neurological disorders, who underwent cardiac surgery and CPB in whom blood samples for S100B and adiponectin (ADN) measurement were drawn at five perioperative time-points.
Results.
S100B showed a significant increase from hospital admission up to 24 h after procedure reaching its maximum peak (P<0.01) during CPB and at the end of the surgical procedure.
Moreover, ADN showed a flat pattern and no significant differences (P>0.05) have been found all along perioperative monitoring.
ADN/S100B ratio pattern was identical to S100B alone with the higher peak at the end of CPB and remained higher up to 24 h from surgery.
Conclusions.
The present study provides evidence that, in CHD infants, S100B protein is not affected by an extra-source adipose tissue release as suggested by no changes in circulating ADN concentrations.
American Psychological Association (APA)
Varrica, Alessandro& Satriano, Angela& Frigiola, Alessandro& Giamberti, Alessandro& Tettamanti, Guido& Anastasia, Luigi…[et al.]. 2015. Circulating S100B and Adiponectin in Children Who Underwent Open Heart Surgery and Cardiopulmonary Bypass. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055342
Modern Language Association (MLA)
Varrica, Alessandro…[et al.]. Circulating S100B and Adiponectin in Children Who Underwent Open Heart Surgery and Cardiopulmonary Bypass. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055342
American Medical Association (AMA)
Varrica, Alessandro& Satriano, Angela& Frigiola, Alessandro& Giamberti, Alessandro& Tettamanti, Guido& Anastasia, Luigi…[et al.]. Circulating S100B and Adiponectin in Children Who Underwent Open Heart Surgery and Cardiopulmonary Bypass. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055342