All-Trans Retinoic Acid Induces Proliferation, Survival, and Migration in A549 Lung Cancer Cells by Activating the ERK Signaling Pathway through a Transcription-Independent Mechanism
Joint Authors
Quintero Barceinas, Reyna Sara
García-Regalado, Alejandro
Aréchaga-Ocampo, Elena
Villegas-Sepúlveda, Nicolás
González-De la Rosa, Claudia Haydée
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
All-trans retinoic acid (ATRA) has been used as an antineoplastic because of its ability to promote proliferation, inhibition, and differentiation, primarily in leukemia; however, in other types of cancer, such as lung cancer, treatment with ATRA is restricted because not all the patients experience the same results.
The ERK signaling pathway is dysregulated in cancer cells, including lung cancer, and this dysregulation promotes proliferation and cell invasion.
In this study, we demonstrate that treatment with ATRA can activate the ERK signaling pathway by a transcription-independent mechanism through a signaling cascade that involves RARα and PI3K, promoting growth, survival, and migration in lung cancer cells.
Until now, this mechanism was unknown in lung cancer cells.
The inhibition of the ERK signaling pathway restores the beneficial effects of ATRA, reduces proliferation, increases apoptosis, and blocks the cell migration process in lung cancer cells.
In conclusion, our results suggest that the combination of ATRA with ERK inhibitor in clinical trials for lung cancer is warranted.
American Psychological Association (APA)
Quintero Barceinas, Reyna Sara& García-Regalado, Alejandro& Aréchaga-Ocampo, Elena& Villegas-Sepúlveda, Nicolás& González-De la Rosa, Claudia Haydée. 2015. All-Trans Retinoic Acid Induces Proliferation, Survival, and Migration in A549 Lung Cancer Cells by Activating the ERK Signaling Pathway through a Transcription-Independent Mechanism. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055356
Modern Language Association (MLA)
Quintero Barceinas, Reyna Sara…[et al.]. All-Trans Retinoic Acid Induces Proliferation, Survival, and Migration in A549 Lung Cancer Cells by Activating the ERK Signaling Pathway through a Transcription-Independent Mechanism. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055356
American Medical Association (AMA)
Quintero Barceinas, Reyna Sara& García-Regalado, Alejandro& Aréchaga-Ocampo, Elena& Villegas-Sepúlveda, Nicolás& González-De la Rosa, Claudia Haydée. All-Trans Retinoic Acid Induces Proliferation, Survival, and Migration in A549 Lung Cancer Cells by Activating the ERK Signaling Pathway through a Transcription-Independent Mechanism. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055356