Experience of Preimplantation Genetic Diagnosis for Hemophilia at the University Hospital Virgen Del Rocío in Spain: Technical and Clinical Overview
Joint Authors
García-Lozano, Juan Carlos
Peciña, Ana
Antiñolo, Guillermo
Lozano-Arana, Maria Dolores
Pérez-Garrido, Rosario
Núñez, Ramiro
Borrego, Salud
Sánchez, Beatriz
Fernández, Raquel María
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hemophilia A and B are the most common hereditary hemorrhagic disorders, with an X-linked mode of inheritance.
Reproductive options for the families affected with hemophilia, aiming at the prevention of the birth of children with severe coagulation disorders, include preimplantation genetic diagnosis (PGD).
Here we present the results of our PGD Program applied to hemophilia, at the Department of Genetics, Reproduction and Fetal Medicine of the University Hospital Virgen del Rocío in Seville.
A total of 34 couples have been included in our program since 2005 (30 for hemophilia A and 4 for hemophilia B).
Overall, 60 cycles were performed, providing a total of 508 embryos.
The overall percentage of transfers per cycle was 81.7% and the live birth rate per cycle ranged from 10.3 to 24.1% depending on the methodological approach applied.
Although PGD for hemophilia can be focused on gender selection of female embryos, our results demonstrate that methodological approaches that allow the diagnosis of the hemophilia status of every embryo have notorious advantages.
Our PGD Program resulted in the birth of 12 healthy babies for 10 out of the 34 couples (29.4%), constituting a relevant achievement for the Spanish Public Health System within the field of haematological disorders.
American Psychological Association (APA)
Fernández, Raquel María& Peciña, Ana& Sánchez, Beatriz& Lozano-Arana, Maria Dolores& García-Lozano, Juan Carlos& Pérez-Garrido, Rosario…[et al.]. 2015. Experience of Preimplantation Genetic Diagnosis for Hemophilia at the University Hospital Virgen Del Rocío in Spain: Technical and Clinical Overview. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055359
Modern Language Association (MLA)
Fernández, Raquel María…[et al.]. Experience of Preimplantation Genetic Diagnosis for Hemophilia at the University Hospital Virgen Del Rocío in Spain: Technical and Clinical Overview. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055359
American Medical Association (AMA)
Fernández, Raquel María& Peciña, Ana& Sánchez, Beatriz& Lozano-Arana, Maria Dolores& García-Lozano, Juan Carlos& Pérez-Garrido, Rosario…[et al.]. Experience of Preimplantation Genetic Diagnosis for Hemophilia at the University Hospital Virgen Del Rocío in Spain: Technical and Clinical Overview. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055359