NOD-Like Receptor Signaling in Cholesteatoma
Joint Authors
Sudhoff, H.
Bruchhage, Karl-Ludwig
Leichtle, Anke
Klenke, Christin
Ebmeyer, Joerg
Daerr, Markus
Hoffmann, Anna Sophie
Ryan, Allen F.
Wollenberg, Barbara
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Cholesteatoma is a destructive process of the middle ear resulting in erosion of the surrounding bony structures with consequent hearing loss, vestibular dysfunction, facial paralysis, or intracranial complications.
The etiopathogenesis of cholesteatoma is controversial but is associated with recurrent ear infections.
The role of intracellular innate immune receptors, the NOD-like receptors, and their associated signaling networks was investigated in cholesteatoma, since mutations in NOD-like receptor-related genes have been implicated in other chronic inflammatory disorders.
Results.
The expression of NOD2 mRNA and protein was significantly induced in cholesteatoma compared to the external auditory canal skin, mainly located in the epithelial layer of cholesteatoma.
Microarray analysis showed significant upregulation for NOD2, not for NOD1, TLR2, or TLR4 in cholesteatoma.
Moreover, regulation of genes in an interaction network of the NOD-adaptor molecule RIPK2 was detected.
In addition to NOD2, NLRC4, and PYCARD, the downstream molecules IRAK1 and antiapoptotic regulator CFLAR showed significant upregulation, whereas SMAD3, a proapoptotic inducer, was significantly downregulated.
Finally, altered regulation of inflammatory target genes of NOD signaling was detected.
Conclusions.
These results indicate that the interaction of innate immune signaling mediated by NLRs and their downstream target molecules is involved in the etiopathogenesis and growth of cholesteatoma.
American Psychological Association (APA)
Leichtle, Anke& Klenke, Christin& Ebmeyer, Joerg& Daerr, Markus& Bruchhage, Karl-Ludwig& Hoffmann, Anna Sophie…[et al.]. 2015. NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055368
Modern Language Association (MLA)
Leichtle, Anke…[et al.]. NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055368
American Medical Association (AMA)
Leichtle, Anke& Klenke, Christin& Ebmeyer, Joerg& Daerr, Markus& Bruchhage, Karl-Ludwig& Hoffmann, Anna Sophie…[et al.]. NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055368