NOD-Like Receptor Signaling in Cholesteatoma

Joint Authors

Sudhoff, H.
Bruchhage, Karl-Ludwig
Leichtle, Anke
Klenke, Christin
Ebmeyer, Joerg
Daerr, Markus
Hoffmann, Anna Sophie
Ryan, Allen F.
Wollenberg, Barbara

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-04-02

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Background.

Cholesteatoma is a destructive process of the middle ear resulting in erosion of the surrounding bony structures with consequent hearing loss, vestibular dysfunction, facial paralysis, or intracranial complications.

The etiopathogenesis of cholesteatoma is controversial but is associated with recurrent ear infections.

The role of intracellular innate immune receptors, the NOD-like receptors, and their associated signaling networks was investigated in cholesteatoma, since mutations in NOD-like receptor-related genes have been implicated in other chronic inflammatory disorders.

Results.

The expression of NOD2 mRNA and protein was significantly induced in cholesteatoma compared to the external auditory canal skin, mainly located in the epithelial layer of cholesteatoma.

Microarray analysis showed significant upregulation for NOD2, not for NOD1, TLR2, or TLR4 in cholesteatoma.

Moreover, regulation of genes in an interaction network of the NOD-adaptor molecule RIPK2 was detected.

In addition to NOD2, NLRC4, and PYCARD, the downstream molecules IRAK1 and antiapoptotic regulator CFLAR showed significant upregulation, whereas SMAD3, a proapoptotic inducer, was significantly downregulated.

Finally, altered regulation of inflammatory target genes of NOD signaling was detected.

Conclusions.

These results indicate that the interaction of innate immune signaling mediated by NLRs and their downstream target molecules is involved in the etiopathogenesis and growth of cholesteatoma.

American Psychological Association (APA)

Leichtle, Anke& Klenke, Christin& Ebmeyer, Joerg& Daerr, Markus& Bruchhage, Karl-Ludwig& Hoffmann, Anna Sophie…[et al.]. 2015. NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055368

Modern Language Association (MLA)

Leichtle, Anke…[et al.]. NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055368

American Medical Association (AMA)

Leichtle, Anke& Klenke, Christin& Ebmeyer, Joerg& Daerr, Markus& Bruchhage, Karl-Ludwig& Hoffmann, Anna Sophie…[et al.]. NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055368

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1055368