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Ca2+ Signaling in Cytoskeletal Reorganization, Cell Migration, and Cancer Metastasis
Joint Authors
Tsai, Feng-Chiao
Kuo, Guan-Hung
Chang, Shu-Wei
Tsai, Pei-Ju
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Proper control of Ca2+ signaling is mandatory for effective cell migration, which is critical for embryonic development, wound healing, and cancer metastasis.
However, how Ca2+ coordinates structural components and signaling molecules for proper cell motility had remained elusive.
With the advance of fluorescent live-cell Ca2+ imaging in recent years, we gradually understand how Ca2+ is regulated spatially and temporally in migrating cells, driving polarization, protrusion, retraction, and adhesion at the right place and right time.
Here we give an overview about how cells create local Ca2+ pulses near the leading edge, maintain cytosolic Ca2+ gradient from back to front, and restore Ca2+ depletion for persistent cell motility.
Differential roles of Ca2+ in regulating various effectors and the interaction of roles of Ca2+ signaling with other pathways during migration are also discussed.
Such information might suggest a new direction to control cancer metastasis by manipulating Ca2+ and its associating signaling molecules in a judicious manner.
American Psychological Association (APA)
Tsai, Feng-Chiao& Kuo, Guan-Hung& Chang, Shu-Wei& Tsai, Pei-Ju. 2015. Ca2+ Signaling in Cytoskeletal Reorganization, Cell Migration, and Cancer Metastasis. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055373
Modern Language Association (MLA)
Tsai, Feng-Chiao…[et al.]. Ca2+ Signaling in Cytoskeletal Reorganization, Cell Migration, and Cancer Metastasis. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055373
American Medical Association (AMA)
Tsai, Feng-Chiao& Kuo, Guan-Hung& Chang, Shu-Wei& Tsai, Pei-Ju. Ca2+ Signaling in Cytoskeletal Reorganization, Cell Migration, and Cancer Metastasis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055373