Impairment of Neutrophil Migration to Remote Inflammatory Site during Lung Histoplasmosis
Joint Authors
Medeiros, Alexandra I.
Bélanger, Caroline
Borgeat, Pierre
Marleau, Sylvie
Artério Sorgi, Carlos
Faccioli, Lúcia Helena
Secatto, Adriana
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Histoplasma capsulatum (Hc) induces a pulmonary disease in which leukotrienes promote activation and recruitment of effectors cells.
It is also well-recognized that leukotriene B4 (LTB4) and platelet-activating factor (PAF) induce leukocyte recruitment to inflammatory sites.
We investigated the impact of pulmonary Hc infection on PMN migration to a remote inflammatory site.
Our results show that pulmonary Hc infection impairs LTB4- or PAF-stimulated PMN recruitment to air pouch.
Yet, remote inflammation did not modify PMN numbers in the bronchoalveolar lavage fluid (BALF) of Hc-infected mice.
Interestingly, the concomitant administration of PAF and LTB4 receptor antagonists inhibited PMN recruitment to both BALF and the remote site, demonstrating cooperation between both mediators.
Along that line, our results show that PAF-elicited PMN chemotaxis was abrogated in 5-lipoxygenase-deficient animals.
These results suggest caution in the indiscriminate use of anti-inflammatory drugs during infectious diseases.
American Psychological Association (APA)
Medeiros, Alexandra I.& Secatto, Adriana& Bélanger, Caroline& Artério Sorgi, Carlos& Borgeat, Pierre& Marleau, Sylvie…[et al.]. 2015. Impairment of Neutrophil Migration to Remote Inflammatory Site during Lung Histoplasmosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055374
Modern Language Association (MLA)
Medeiros, Alexandra I.…[et al.]. Impairment of Neutrophil Migration to Remote Inflammatory Site during Lung Histoplasmosis. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055374
American Medical Association (AMA)
Medeiros, Alexandra I.& Secatto, Adriana& Bélanger, Caroline& Artério Sorgi, Carlos& Borgeat, Pierre& Marleau, Sylvie…[et al.]. Impairment of Neutrophil Migration to Remote Inflammatory Site during Lung Histoplasmosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055374