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mir-21 Overexpressing Mesenchymal Stem Cells Accelerate Fracture Healing in a Rat Closed Femur Fracture Model
Joint Authors
Li, Gang
Sun, Yuxin
Xu, Liangliang
Huang, Shuo
Hou, Yonghui
Liu, Yang
Chan, Kai-Ming
Pan, Xiao-Hua
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
MicroRNAs are small noncoding RNAs involved in numerous biological processes.
Emerging pieces of evidence suggest that microRNAs play important roles in osteogenesis and skeletal homeostasis.
Recent studies indicated the significant regulation function of mir-21 in osteogenesis in vitro, but little information is known about its veritable functions in vivo.
In the present study, we aimed to investigate the effect of mir-21 intervention on osteogenic differentiation of rats bone marrow derived mesenchymal stem cells (rBMSCs) and repair capacity in rats closed femur fracture model with internal fixation.
The results showed that the upregulation of mir-21 not only increased the expression of osteopontin and alkaline phosphatase in rBMSCs but also promoted mineralization in the condition of osteogenic induction.
Furthermore, the bone healing properties were also improved in fracture healing model according to the results of micro-CT, mechanical test, and histological analysis.
The current study confirms that the overexpression of mir-21 could promote osteogenesis and accelerate bone fracture healing, which may contribute to a new therapeutic way for fracture repair.
American Psychological Association (APA)
Sun, Yuxin& Xu, Liangliang& Huang, Shuo& Hou, Yonghui& Liu, Yang& Chan, Kai-Ming…[et al.]. 2015. mir-21 Overexpressing Mesenchymal Stem Cells Accelerate Fracture Healing in a Rat Closed Femur Fracture Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055378
Modern Language Association (MLA)
Sun, Yuxin…[et al.]. mir-21 Overexpressing Mesenchymal Stem Cells Accelerate Fracture Healing in a Rat Closed Femur Fracture Model. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055378
American Medical Association (AMA)
Sun, Yuxin& Xu, Liangliang& Huang, Shuo& Hou, Yonghui& Liu, Yang& Chan, Kai-Ming…[et al.]. mir-21 Overexpressing Mesenchymal Stem Cells Accelerate Fracture Healing in a Rat Closed Femur Fracture Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055378