Morphological and Biomechanical Differences in the Elastase and AngII apoE−− Rodent Models of Abdominal Aortic Aneurysms
Joint Authors
Goergen, Craig J.
Phillips, Evan H.
Yrineo, Alexa A.
Schroeder, Hilary D.
Wilson, Katherine E.
Cheng, Ji-Xin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
An abdominal aortic aneurysm (AAA) is a potentially fatal cardiovascular disease with multifactorial development and progression.
Two preclinical models of the disease (elastase perfusion and angiotensin II infusion in apolipoprotein-E-deficient animals) have been developed to study the disease during its initiation and progression.
To date, most studies have used ex vivo methods to examine disease characteristics such as expanded aortic diameter or analytic methods to look at circulating biomarkers.
Herein, we provide evidence from in vivo ultrasound studies of the temporal changes occurring in biomechanical parameters and macromolecules of the aortic wall in each model.
We present findings from 28-day studies in elastase-perfused rats and AngII apoE−/− mice.
While each model develops AAAs specific to their induction method, they both share characteristics with human aneurysms, such as marked changes in vessel strain and blood flow velocity.
Histology and nonlinear microscopy confirmed that both elastin and collagen, both important extracellular matrix molecules, are similarly affected in their levels and spatial distribution.
Future studies could make use of the differences between these models in order to investigate mechanisms of disease progression or evaluate potential AAA treatments.
American Psychological Association (APA)
Phillips, Evan H.& Yrineo, Alexa A.& Schroeder, Hilary D.& Wilson, Katherine E.& Cheng, Ji-Xin& Goergen, Craig J.. 2015. Morphological and Biomechanical Differences in the Elastase and AngII apoE−− Rodent Models of Abdominal Aortic Aneurysms. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055386
Modern Language Association (MLA)
Phillips, Evan H.…[et al.]. Morphological and Biomechanical Differences in the Elastase and AngII apoE−− Rodent Models of Abdominal Aortic Aneurysms. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055386
American Medical Association (AMA)
Phillips, Evan H.& Yrineo, Alexa A.& Schroeder, Hilary D.& Wilson, Katherine E.& Cheng, Ji-Xin& Goergen, Craig J.. Morphological and Biomechanical Differences in the Elastase and AngII apoE−− Rodent Models of Abdominal Aortic Aneurysms. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055386