Successive Intramuscular Boosting with IFN-Alpha Protects Mycobacterium bovis BCG-Vaccinated Mice against M. lepraemurium Infection
Joint Authors
Rangel-Moreno, J.
Islas-Trujillo, S.
Rojas-Espinosa, Ó.
Guerrero, G. G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Leprosy caused by Mycobacterium leprae primarily affects the skin and peripheral nerves.
As a human infectious disease, it is still a significant health and economic burden on developing countries.
Although multidrug therapy is reducing the number of active cases to approximately 0.5 million, the number of cases per year is not declining.
Therefore, alternative host-directed strategies should be addressed to improve treatment efficacy and outcome.
In this work, using murine leprosy as a model, a very similar granulomatous skin lesion to human leprosy, we have found that successive IFN-alpha boosting protects BCG-vaccinated mice against M.
lepraemurium infection.
No difference in the seric isotype and all IgG subclasses measured, neither in the TH1 nor in the TH2 type cytokine production, was seen.
However, an enhanced iNOS/NO production in BCG-vaccinated/i.m.
IFN-alpha boosted mice was observed.
The data provided in this study suggest a promising use for IFN-alpha boosting as a new prophylactic alternative to be explored in human leprosy by targeting host innate cell response.
American Psychological Association (APA)
Guerrero, G. G.& Rangel-Moreno, J.& Islas-Trujillo, S.& Rojas-Espinosa, Ó.. 2015. Successive Intramuscular Boosting with IFN-Alpha Protects Mycobacterium bovis BCG-Vaccinated Mice against M. lepraemurium Infection. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055392
Modern Language Association (MLA)
Guerrero, G. G.…[et al.]. Successive Intramuscular Boosting with IFN-Alpha Protects Mycobacterium bovis BCG-Vaccinated Mice against M. lepraemurium Infection. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055392
American Medical Association (AMA)
Guerrero, G. G.& Rangel-Moreno, J.& Islas-Trujillo, S.& Rojas-Espinosa, Ó.. Successive Intramuscular Boosting with IFN-Alpha Protects Mycobacterium bovis BCG-Vaccinated Mice against M. lepraemurium Infection. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055392