Prospects of HA-Based Universal Influenza Vaccine
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Current influenza vaccines afford substantial protection in humans by inducing strain-specific neutralizing antibodies (Abs).
Most of these Abs target highly variable immunodominant epitopes in the globular domain of the viral hemagglutinin (HA).
Therefore, current vaccines may not be able to induce heterosubtypic immunity against the divergent influenza subtypes.
The identification of broadly neutralizing Abs (BnAbs) against influenza HA using recent technological advancements in antibody libraries, hybridoma, and isolation of single Ab-secreting plasma cells has increased the interest in developing a universal influenza vaccine as it could provide life-long protection.
While these BnAbs can serve as a source for passive immunotherapy, their identification represents an important step towards the design of such a universal vaccine.
This review describes the recent advances and approaches used in the development of universal influenza vaccine based on highly conserved HA regions identified by BnAbs.
American Psychological Association (APA)
Hashem, Anwar M.. 2015. Prospects of HA-Based Universal Influenza Vaccine. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055394
Modern Language Association (MLA)
Hashem, Anwar M.. Prospects of HA-Based Universal Influenza Vaccine. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055394
American Medical Association (AMA)
Hashem, Anwar M.. Prospects of HA-Based Universal Influenza Vaccine. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055394