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T Helper 17Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage
Joint Authors
Gónzalez-Mateo, Guadalupe
Liappas, G.
Majano, Pedro
Sánchez- Tomero, José Antonio
Rodrigues Díez, Raquel
Martín, Pilar
Sanchez-Díaz, Raquel
Selgas, Rafael
López-Cabrera, Manuel
Aguilera Peralta, Abelardo
Ruiz-Ortega, Marta
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fibrosis is a general complication in many diseases.
It is the main complication during peritoneal dialysis (PD) treatment, a therapy for renal failure disease.
Local inflammation and mesothelial to mesenchymal transition (MMT) are well known key phenomena in peritoneal damage during PD.
New data suggest that, in the peritoneal cavity, inflammatory changes may be regulated at least in part by a delicate balance between T helper 17 and regulatory T cells.
This paper briefly reviews the implication of the Th17/Treg-axis in fibrotic diseases.
Moreover, it compares current evidences described in PD animal experimental models, indicating a loss of Th17/Treg balance (Th17 predominance) leading to peritoneal damage during PD.
In addition, considering the new clinical and animal experimental data, new therapeutic strategies to reduce the Th17 response and increase the regulatory T response are proposed.
Thus, future goals should be to develop new clinical biomarkers to reverse this immune misbalance and reduce peritoneal fibrosis in PD.
American Psychological Association (APA)
Liappas, G.& Gónzalez-Mateo, Guadalupe& Majano, Pedro& Sánchez- Tomero, José Antonio& Ruiz-Ortega, Marta& Rodrigues Díez, Raquel…[et al.]. 2015. T Helper 17Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055403
Modern Language Association (MLA)
Liappas, G.…[et al.]. T Helper 17Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055403
American Medical Association (AMA)
Liappas, G.& Gónzalez-Mateo, Guadalupe& Majano, Pedro& Sánchez- Tomero, José Antonio& Ruiz-Ortega, Marta& Rodrigues Díez, Raquel…[et al.]. T Helper 17Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055403