Analysis of the Influence of Hormone Replacement Therapy on Osteocalcin Gene Expression in Postmenopausal Women
Joint Authors
Rahnama, Mansur
Jastrzębska-Jamrogiewicz, Izabela
Jamrogiewicz, Rafał
Trybek, Grzegorz
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Osteocalcin (OC) contributes to the process of bone mineralization.
Present study was designed to investigate the changes in OC gene expression of postmenopausal women treated with hormone replacement therapy (HRT).
Study was also designed to evaluate OC gene expression in cells which are not part of connective tissue.
Material and Methods.
Research was carried out on 30 postmenopausal women not treated and 30 treated with HRT.
Examination of OC gene expression was conducted on peripheral blood lymphocytes (PBL) and buccal epithelial lining (BEL).
Densitometry was conducted on femur and mandible.
Results.
Tests revealed OC gene expression in BEL and PBL.
BMD was higher in groups treated with HRT.
Assessment of correlation between the OC gene expression in BEL and BMD of mandible revealed significant positive relation.
Conclusions.
OC gene expression can be stated BEL and PBL.
Analysis of correlation between OC gene expression in oral cavity and mandible BMD showed significant correlation between local OC expression and local bone metabolism.
The relation between OC gene expression and bone metabolism is complex and further research is needed to clear all of the uncertainties.
American Psychological Association (APA)
Rahnama, Mansur& Jastrzębska-Jamrogiewicz, Izabela& Jamrogiewicz, Rafał& Trybek, Grzegorz. 2015. Analysis of the Influence of Hormone Replacement Therapy on Osteocalcin Gene Expression in Postmenopausal Women. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055406
Modern Language Association (MLA)
Rahnama, Mansur…[et al.]. Analysis of the Influence of Hormone Replacement Therapy on Osteocalcin Gene Expression in Postmenopausal Women. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055406
American Medical Association (AMA)
Rahnama, Mansur& Jastrzębska-Jamrogiewicz, Izabela& Jamrogiewicz, Rafał& Trybek, Grzegorz. Analysis of the Influence of Hormone Replacement Therapy on Osteocalcin Gene Expression in Postmenopausal Women. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055406