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Autophagy and Liver Ischemia-Reperfusion Injury
Joint Authors
Gugenheim, Jean
Colosetti, Pascal
Cursio, Raffaele
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Liver ischemia-reperfusion (I-R) injury occurs during liver resection, liver transplantation, and hemorrhagic shock.
The main mode of liver cell death after warm and/or cold liver I-R is necrosis, but other modes of cell death, as apoptosis and autophagy, are also involved.
Autophagy is an intracellular self-digesting pathway responsible for removal of long-lived proteins, damaged organelles, and malformed proteins during biosynthesis by lysosomes.
Autophagy is found in normal and diseased liver.
Although depending on the type of ischemia, warm and/or cold, the dynamic process of liver I-R results mainly in adenosine triphosphate depletion and in production of reactive oxygen species (ROS), leads to both, a local ischemic insult and an acute inflammatory-mediated reperfusion injury, and results finally in cell death.
This process can induce liver dysfunction and can increase patient morbidity and mortality after liver surgery and hemorrhagic shock.
Whether autophagy protects from or promotes liver injury following warm and/or cold I-R remains to be elucidated.
The present review aims to summarize the current knowledge in liver I-R injury focusing on both the beneficial and the detrimental effects of liver autophagy following warm and/or cold liver I-R.
American Psychological Association (APA)
Cursio, Raffaele& Colosetti, Pascal& Gugenheim, Jean. 2015. Autophagy and Liver Ischemia-Reperfusion Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1055410
Modern Language Association (MLA)
Cursio, Raffaele…[et al.]. Autophagy and Liver Ischemia-Reperfusion Injury. BioMed Research International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1055410
American Medical Association (AMA)
Cursio, Raffaele& Colosetti, Pascal& Gugenheim, Jean. Autophagy and Liver Ischemia-Reperfusion Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1055410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055410