Evaluation of the Effect of Hypercapnia on Vascular Function in Normal Tension Glaucoma
Joint Authors
Quill, B.
Henry, E.
Simon, E.
O'Brien, Colm
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
Altered ocular perfusion and vascular dysregulation have been reported in glaucoma.
The aim of this paper was to evaluate the vascular response to a hypercapnic stimulus.
Methods.
Twenty normal tension glaucoma (NTG) patients and eighteen age- and gender-matched controls had pulsatile ocular blood flow (POBF) measurements, systemic cardiovascular assessment, and laser Doppler digital blood flow (DBF) assessed.
Measurements were taken at baseline, after 10-minutes rest, in the stable sitting and supine positions and following induction and stabilization of hypercapnia, which induced a 15% increase in end-tidal pCO2.
The POBF response to hypercapnia was divided into high (>20%) and low responders (<20%).
Results.
65% of NTG patients had a greater than 41% increase in POBF following CO2 rebreathing (high responders).
These high responders had a lower baseline POBF, lower baseline DBF, and a greater DBF response to thermal stimulus.
Conclusion.
NTG patients that have a greater than 20% increase in POBF after a hypercapnic stimulus have lower baseline POBF and DBF values.
This suggests that there is impaired regulation of blood flow in a significant subgroup of NTG patients.
This observation may reflect a generalised dysfunction of the vascular endothelium.
American Psychological Association (APA)
Quill, B.& Henry, E.& Simon, E.& O'Brien, Colm. 2015. Evaluation of the Effect of Hypercapnia on Vascular Function in Normal Tension Glaucoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055414
Modern Language Association (MLA)
Quill, B.…[et al.]. Evaluation of the Effect of Hypercapnia on Vascular Function in Normal Tension Glaucoma. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055414
American Medical Association (AMA)
Quill, B.& Henry, E.& Simon, E.& O'Brien, Colm. Evaluation of the Effect of Hypercapnia on Vascular Function in Normal Tension Glaucoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055414