Drug Susceptibility Testing of 31 Antimicrobial Agents on Rapidly Growing Mycobacteria Isolates from China
Joint Authors
Pang, Hui
Li, Guilian
Zhao, Xiuqin
Liu, Haican
Wan, Kanglin
Yu, Ping
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
Several species of rapidly growing mycobacteria (RGM) are now recognized as human pathogens.
However, limited data on effective drug treatments against these organisms exists.
Here, we describe the species distribution and drug susceptibility profiles of RGM clinical isolates collected from four southern Chinese provinces from January 2005 to December 2012.
Methods.
Clinical isolates (73) were subjected to in vitro testing with 31 antimicrobial agents using the cation-adjusted Mueller-Hinton broth microdilution method.
The isolates included 55 M.
abscessus, 11 M.
fortuitum, 3 M.
chelonae, 2 M.
neoaurum, and 2 M.
septicum isolates.
Results.
M.
abscessus (75.34%) and M.
fortuitum (15.07%), the most common species, exhibited greater antibiotic resistance than the other three species.
The isolates had low resistance to amikacin, linezolid, and tigecycline, and high resistance to first-line antituberculous agents, amoxicillin-clavulanic acid, rifapentine, dapsone, thioacetazone, and pasiniazid.
M.
abscessus and M.
fortuitum were highly resistant to ofloxacin and rifabutin, respectively.
The isolates showed moderate resistance to the other antimicrobial agents.
Conclusions.
Our results suggest that tigecycline, linezolid, clofazimine, and cefmetazole are appropriate choices for M.
abscessus infections.
Capreomycin, sulfamethoxazole, tigecycline, clofazimine, and cefmetazole are potentially good choices for M.
fortuitum infections.
Our drug susceptibility data should be useful to clinicians.
American Psychological Association (APA)
Pang, Hui& Li, Guilian& Zhao, Xiuqin& Liu, Haican& Wan, Kanglin& Yu, Ping. 2015. Drug Susceptibility Testing of 31 Antimicrobial Agents on Rapidly Growing Mycobacteria Isolates from China. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055422
Modern Language Association (MLA)
Pang, Hui…[et al.]. Drug Susceptibility Testing of 31 Antimicrobial Agents on Rapidly Growing Mycobacteria Isolates from China. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055422
American Medical Association (AMA)
Pang, Hui& Li, Guilian& Zhao, Xiuqin& Liu, Haican& Wan, Kanglin& Yu, Ping. Drug Susceptibility Testing of 31 Antimicrobial Agents on Rapidly Growing Mycobacteria Isolates from China. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055422