The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients
Joint Authors
Chuang, Jiin-Haur
Chen, Chih-Jen
Huang, Ying-Hsien
Tang, Kuo-Shu
Tiao, Mao-Meng
Chen, Chao-Long
Huang, Li-Tung
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
Cholestatic liver injury is associated with a high production of free radicals.
The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined.
The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occur during the development of BA and after liver transplantation (LT).
Methods.
We enrolled BA patients and control subjects and collected their clinical information.
The activities of antioxidant enzymes in BA patients before LT (BA group) and after LT (LT group) were analyzed.
Results.
The number of mitochondrial DNA copies had increased in the LT group compared with the BA group.
Similarly, the activity of glutathione peroxidase had increased in the LT group compared with the BA group.
The level of glutathione was higher in the LT group than in the BA group.
Malondialdehyde levels were decreased in the LT group compared with the BA group.
Conclusions.
These data indicate that LT is associated with increased antioxidant enzyme activities and decreased malondialdehyde levels in BA patients.
The manipulation of mitochondria-associated antioxidative activity might be an important future management strategy for BA.
American Psychological Association (APA)
Chen, Chih-Jen& Tang, Kuo-Shu& Huang, Ying-Hsien& Chen, Chao-Long& Huang, Li-Tung& Chuang, Jiin-Haur…[et al.]. 2015. The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055430
Modern Language Association (MLA)
Chen, Chih-Jen…[et al.]. The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055430
American Medical Association (AMA)
Chen, Chih-Jen& Tang, Kuo-Shu& Huang, Ying-Hsien& Chen, Chao-Long& Huang, Li-Tung& Chuang, Jiin-Haur…[et al.]. The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055430