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Osteoprotective Effect of Cordycepin on Estrogen Deficiency-Induced Osteoporosis In Vitro and In Vivo
Joint Authors
Zhang, Da-wei
Deng, Hualiang
Qi, Wei
Zhao, Guang-yue
Cao, Xiao-rui
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The purpose of this study was to verify the effect of cordycepin on ovariectomized osteopenic rats.
Fifty Wistar female rats used were divided into 5 groups: (1) sham-operation rats (control), (2) ovariectomized (OVX) rats with osteopenia, and (3) OVX’d rats with osteopenia treated with cordycepin (5 mg, 10 mg, and 20 mg) for 8 weeks.
After the rats were treated orally with cordycepin, serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine (HCY) , C-terminal crosslinked telopeptides of collagen type I (CTX) level, and oxidative stress were examined, respectively.
The femoral neck was used for mechanical compression testing.
At the same time, we further investigated the effect of cordycepin in vitro assay.
The beneficial effects of cordycepin on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, and CTX level.
At the same time, cordycepin also increases the OC level in ovariectomized osteopenic rats.
The histological examination clearly showed that dietary cordycepin can prevent bone loss caused by estrogen deficiency.
These experimental results suggest that complement cordycepin is protective after ovariectomized osteopenic in specific way.
American Psychological Association (APA)
Zhang, Da-wei& Deng, Hualiang& Qi, Wei& Zhao, Guang-yue& Cao, Xiao-rui. 2015. Osteoprotective Effect of Cordycepin on Estrogen Deficiency-Induced Osteoporosis In Vitro and In Vivo. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055436
Modern Language Association (MLA)
Zhang, Da-wei…[et al.]. Osteoprotective Effect of Cordycepin on Estrogen Deficiency-Induced Osteoporosis In Vitro and In Vivo. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055436
American Medical Association (AMA)
Zhang, Da-wei& Deng, Hualiang& Qi, Wei& Zhao, Guang-yue& Cao, Xiao-rui. Osteoprotective Effect of Cordycepin on Estrogen Deficiency-Induced Osteoporosis In Vitro and In Vivo. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055436