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Progesterone and Src Family Inhibitor PP1 Synergistically Inhibit Cell Migration and Invasion of Human Basal Phenotype Breast Cancer Cells
Joint Authors
Xie, Mingxuan
Zhou, Li
Chen, Xi
Gainey, Lindsey O.
Xiao, Jian
Nanes, Mark S.
Hou, Anji
You, Shaojin
Chen, Qiong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Basal phenotype breast cancer is one of the most aggressive breast cancers that frequently metastasize to brain.
The role of sex hormones and their receptors in development of this disease is largely unclear.
We demonstrated that mPRα was expressed at a moderate level in a brain metastatic BPBC cell line MB231Br, which was derived from the parent mPRα undetectable MB231 cells.
It functioned as an essential mediator for progesterone induced inhibitory effects on cell migration of MB231Br and, when coincubated with PP1, synergistically enhanced the progesterone’s inhibitory effect on cell migration and invasion in vitro.
Progesterone and PP1 cotreatment induced a cascade of molecular signaling events, such as dephosphorylation of FAK, downregulation of MMP9, VEGF, and KCNMA1 expressions.
Our in vitro study demonstrated that mPRα was expressed and functioned as an essential mediator for progesterone induced inhibitory effects on cell migration and invasion in BPBC cells.
This inhibitory effect was enhanced by PP1 via FAK dephosphorylation, MMP9, VEGF, and KCNMA1 downregulation mechanisms.
Our study provides a new clue toward the development of novel promising agents and pathways for inhibiting nuclear hormonal receptor-negative and endocrine-resistant breast cancers.
American Psychological Association (APA)
Xie, Mingxuan& Zhou, Li& Chen, Xi& Gainey, Lindsey O.& Xiao, Jian& Nanes, Mark S.…[et al.]. 2015. Progesterone and Src Family Inhibitor PP1 Synergistically Inhibit Cell Migration and Invasion of Human Basal Phenotype Breast Cancer Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055444
Modern Language Association (MLA)
Xie, Mingxuan…[et al.]. Progesterone and Src Family Inhibitor PP1 Synergistically Inhibit Cell Migration and Invasion of Human Basal Phenotype Breast Cancer Cells. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1055444
American Medical Association (AMA)
Xie, Mingxuan& Zhou, Li& Chen, Xi& Gainey, Lindsey O.& Xiao, Jian& Nanes, Mark S.…[et al.]. Progesterone and Src Family Inhibitor PP1 Synergistically Inhibit Cell Migration and Invasion of Human Basal Phenotype Breast Cancer Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055444