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Regulation of Synthesis and Roles of Hyaluronan in Peritoneal Dialysis
Joint Authors
Sauter, Matthias
Sitter, Thomas
Bowen, Timothy
Meran, Soma
Williams, Aled P.
Newbury, Lucy J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan composed of repeated disaccharide units of alternating D-glucuronic acid and D-N-acetylglucosamine residues linked via alternating β-1,4 and β-1,3 glycosidic bonds.
HA is synthesized in humans by HA synthase (HAS) enzymes 1, 2, and 3, which are encoded by the corresponding HAS genes.
Previous in vitro studies have shown characteristic changes in HAS expression and increased HA synthesis in response to wounding and proinflammatory cytokines in human peritoneal mesothelial cells.
In addition, in vivo models and human peritoneal biopsy samples have provided evidence of changes in HA metabolism in the fibrosis that at present accompanies peritoneal dialysis treatment.
This review discusses these published observations and how they might contribute to improvement in peritoneal dialysis.
American Psychological Association (APA)
Bowen, Timothy& Meran, Soma& Williams, Aled P.& Newbury, Lucy J.& Sauter, Matthias& Sitter, Thomas. 2015. Regulation of Synthesis and Roles of Hyaluronan in Peritoneal Dialysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055446
Modern Language Association (MLA)
Bowen, Timothy…[et al.]. Regulation of Synthesis and Roles of Hyaluronan in Peritoneal Dialysis. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055446
American Medical Association (AMA)
Bowen, Timothy& Meran, Soma& Williams, Aled P.& Newbury, Lucy J.& Sauter, Matthias& Sitter, Thomas. Regulation of Synthesis and Roles of Hyaluronan in Peritoneal Dialysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055446