Positive Association of Vitamin D Receptor Gene Variations with Multiple Sclerosis in South East Iranian Population
Joint Authors
Narooie-Nejad, Mehrnaz
Torkamanzehi, Adam
Moghtaderi, Ali
Moossavi, Maryam
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-20
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Among the factors postulated to play a role in MS susceptibility, the role of vitamin D is outstanding.
Since the function of vitamin D receptor (VDR) represents the effect of vitamin D on the body and genetic variations in VDR gene may affect its function, we aim to highlight the association of two VDR gene polymorphisms with MS susceptibility.
In current study, we recruited 113 MS patients and 122 healthy controls.
TaqI (rs731236) and ApaI (rs7975232) genetic variations in these two groups were evaluated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
All genotype and allele frequencies in both variations showed association with the disease status.
However, to find the definite connection between genetic variations in VDR gene and MS disease in a population of South East of Iran, more researches on gene structure and its function with regard to patients’ conditions are required.
American Psychological Association (APA)
Narooie-Nejad, Mehrnaz& Moossavi, Maryam& Torkamanzehi, Adam& Moghtaderi, Ali. 2015. Positive Association of Vitamin D Receptor Gene Variations with Multiple Sclerosis in South East Iranian Population. BioMed Research International،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1055451
Modern Language Association (MLA)
Narooie-Nejad, Mehrnaz…[et al.]. Positive Association of Vitamin D Receptor Gene Variations with Multiple Sclerosis in South East Iranian Population. BioMed Research International No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1055451
American Medical Association (AMA)
Narooie-Nejad, Mehrnaz& Moossavi, Maryam& Torkamanzehi, Adam& Moghtaderi, Ali. Positive Association of Vitamin D Receptor Gene Variations with Multiple Sclerosis in South East Iranian Population. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1055451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055451