Identification of pLG72-Induced Oxidative Stress Using Systemic Approaches
Joint Authors
Chang, Hao-Teng
Wang, Maofeng
Chen, Hsi-Ju
Zhang, Jun
Li, Weimin
Xie, Xinyou
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
G72 is a schizophrenia-susceptible gene encoding a polypeptide with 153 amino acids.
In 2002, it was originally proposed as an activator of D-amino acid oxidase (DAOA) that could enhance the activity of DAAO and subsequently reduce the neurotransmission of N-methyl-D-aspartate receptors.
However, several controversial findings have been reported recently.
Due to a number of inconsistent descriptions of pLG72’s biofunctions, this study aims to identify the cellular effects induced by pLG72 in U87 cells using systems biology approaches.
The analyses of transcriptomics and biological networks showed that pLG72 might be involved in the induction of oxidative stress.
To confirm the in silico prediction, we tested and discovered that overexpression of pLG72 effectively enhanced reactive oxygen species (ROS) in U87 cells and, furthermore, this induction can be quenched by Tempol, a general ROS scavenger.
Therefore, G72-transgenic mice presenting some psychiatric symptoms, along with the pLG72 level being significantly increased in the serum of patients with schizophrenia, have led us to propose that the ROS enhancement in mental diseases may be from the overexpression of pLG72 in brain cells.
American Psychological Association (APA)
Wang, Maofeng& Chen, Hsi-Ju& Zhang, Jun& Li, Weimin& Xie, Xinyou& Chang, Hao-Teng. 2015. Identification of pLG72-Induced Oxidative Stress Using Systemic Approaches. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055457
Modern Language Association (MLA)
Wang, Maofeng…[et al.]. Identification of pLG72-Induced Oxidative Stress Using Systemic Approaches. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055457
American Medical Association (AMA)
Wang, Maofeng& Chen, Hsi-Ju& Zhang, Jun& Li, Weimin& Xie, Xinyou& Chang, Hao-Teng. Identification of pLG72-Induced Oxidative Stress Using Systemic Approaches. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055457