Effect of Recombinant Prophenin 2 on the Integrity and Viability of Trichomonas vaginalis
Joint Authors
Hernandez-Flores, J. L.
Rodriguez, M. C.
Gastelum Arellanez, A.
Alvarez-Morales, A.
Avila, E. E.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Trichomonas vaginalis is the causal agent of trichomoniasis, which is associated with preterm child delivery, low birth weight, and an increased risk of infection by human papilloma virus and human immunodeficiency virus following exposure.
Several reports have established increasing numbers of trichomoniasis cases resistant to metronidazole, the agent used for treatment, and it is therefore important to identify new therapeutic alternatives.
Previously, our group reported the effect of tritrpticin, a synthetic peptide derived from porcine prophenin, on T.
vaginalis; however, the hemolytic activity of this small peptide complicates its possible use as a therapeutic agent.
In this study, we report that the propeptide and the processed peptide of prophenin 2 (cleaved with hydroxylamine) affected the integrity and growth of T.
vaginalis and that pro-prophenin 2 displays some resistance to proteolysis by T.
vaginalis proteinases at 1 h.
Its effect on T.
vaginalis as well as its low hemolytic activity and short-time stability to parasite proteinases makes prophenin 2 an interesting candidate for synergistic or alternative treatment against T.
vaginalis.
American Psychological Association (APA)
Hernandez-Flores, J. L.& Rodriguez, M. C.& Gastelum Arellanez, A.& Alvarez-Morales, A.& Avila, E. E.. 2015. Effect of Recombinant Prophenin 2 on the Integrity and Viability of Trichomonas vaginalis. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055461
Modern Language Association (MLA)
Hernandez-Flores, J. L.…[et al.]. Effect of Recombinant Prophenin 2 on the Integrity and Viability of Trichomonas vaginalis. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055461
American Medical Association (AMA)
Hernandez-Flores, J. L.& Rodriguez, M. C.& Gastelum Arellanez, A.& Alvarez-Morales, A.& Avila, E. E.. Effect of Recombinant Prophenin 2 on the Integrity and Viability of Trichomonas vaginalis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055461