LAP TGF-Beta Subset of CD4+CD25+CD127− Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients
Joint Authors
Romero-Garcia, Susana
Prado-Garcia, Heriberto
Islas-Vazquez, Lorenzo
Galicia-Velasco, Miriam
Camacho-Mendoza, Catalina
Aguilar-Cazares, Dolores
Lopez-Gonzalez, Jose Sullivan
Meneses-Flores, Manuel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lung cancer is the leading cause of cancer death worldwide.
Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking.
Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells.
This inflammatory environment may contribute to tumor development.
In contrast, some reports indicate that tumors may induce immunosuppressive Treg cells to dampen immune reactivity, supporting tumor growth and progression.
Thus, we aimed to analyze whether chronic inflammation or immunosuppression predominates at the systemic level in lung adenocarcinoma patients, and several cytokines and Th17 and Treg cells were studied.
Higher proportions of IL-17-producing CD4+ T-cells were found in smoking control subjects and in lung adenocarcinoma patients compared to nonsmoking control subjects.
In addition, lung adenocarcinoma patients increased both plasma concentrations of IL-2, IL-4, IL-6, and IL-10, and proportions of Latency Associated Peptide (LAP) TGF-β subset of CD4+CD25+CD127− Treg cells, which overexpressed LAP TGF-β.
This knowledge may lead to the development of immunotherapies that could inhibit the suppressor activity mediated by the LAP TGF-β subset of CD4+CD25+CD127− Treg cells to promote reactivity of immune cells against lung adenocarcinoma cells.
American Psychological Association (APA)
Islas-Vazquez, Lorenzo& Prado-Garcia, Heriberto& Aguilar-Cazares, Dolores& Meneses-Flores, Manuel& Galicia-Velasco, Miriam& Romero-Garcia, Susana…[et al.]. 2015. LAP TGF-Beta Subset of CD4+CD25+CD127− Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055465
Modern Language Association (MLA)
Islas-Vazquez, Lorenzo…[et al.]. LAP TGF-Beta Subset of CD4+CD25+CD127− Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055465
American Medical Association (AMA)
Islas-Vazquez, Lorenzo& Prado-Garcia, Heriberto& Aguilar-Cazares, Dolores& Meneses-Flores, Manuel& Galicia-Velasco, Miriam& Romero-Garcia, Susana…[et al.]. LAP TGF-Beta Subset of CD4+CD25+CD127− Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055465