Burnout Is Associated with Reduced Parasympathetic Activity and Reduced HPA Axis Responsiveness, Predominantly in Males
Joint Authors
de Vente, Wieke
van Amsterdam, Jan G. C.
Olff, Miranda
Kamphuis, Jan H.
Emmelkamp, Paul M. G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
There is mounting evidence that burnout is a risk factor for cardiovascular disease (CVD).
Stress-related dysregulation of the sympathetic and parasympathetic system and the hypothalamic pituitary adrenal (HPA) axis may explain the enhanced risk for CVD.
To test this hypothesis, 55 patients (34 males and 21 females) with burnout on sickness absence and 40 healthy participants (16 males and 24 females) were exposed to a psychosocial stressor consisting of mental arithmetic and public speech.
Physiological variables (i.e., blood pressure, heart rate, cardiac output, vascular resistance, cortisol, and alpha-amylase) were measured.
Basal levels, reactivity, and recovery were compared between groups.
In male patients, baseline systolic blood pressure was higher, whereas basal alpha-amylase and cortisol reactivity were lower than in healthy males.
In female patients, a tendency for lower basal cortisol was found as compared to healthy females.
Furthermore, reduced basal heart rate variability and a trend for elevated basal cardiac output were observed in both male and female patients.
Burnout is characterised by dysregulation of the sympathetic and parasympathetic system and the HPA axis, which was more pronounced in males than in females.
This study further supports burnout as being a risk factor for CVD through dysregulation of the sympathetic and parasympathetic system and the HPA axis.
American Psychological Association (APA)
de Vente, Wieke& van Amsterdam, Jan G. C.& Olff, Miranda& Kamphuis, Jan H.& Emmelkamp, Paul M. G.. 2015. Burnout Is Associated with Reduced Parasympathetic Activity and Reduced HPA Axis Responsiveness, Predominantly in Males. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055467
Modern Language Association (MLA)
de Vente, Wieke…[et al.]. Burnout Is Associated with Reduced Parasympathetic Activity and Reduced HPA Axis Responsiveness, Predominantly in Males. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055467
American Medical Association (AMA)
de Vente, Wieke& van Amsterdam, Jan G. C.& Olff, Miranda& Kamphuis, Jan H.& Emmelkamp, Paul M. G.. Burnout Is Associated with Reduced Parasympathetic Activity and Reduced HPA Axis Responsiveness, Predominantly in Males. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055467