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Prediction of Metabolic Gene Biomarkers for Neurodegenerative Disease by an Integrated Network-Based Approach
Joint Authors
Ni, Qi
Su, Xianming
Chen, Jingqi
Tian, Weidong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Neurodegenerative diseases (NDs), such as Parkinson’s disease (PD) and Huntington’s disease (HD), have become more and more common among aged people worldwide.
One hallmark of NDs is the presence of intracellular accumulation of specific pathogenic proteins that may result from abnormal function of metabolic processes.
Previously, we have developed a computational method named Met-express that predicted key enzyme-coding genes in cancer development by integrating cancer gene coexpression network with the metabolic network.
Here, we applied Met-express to predict key enzyme-coding genes in both PD and HD.
Functional enrichment analysis and literature review of predicted genes suggested that there might be some common pathogenic metabolic pathways for PD and HD.
We further found that the predicted genes had significant functional association with known disease genes, with some of them already documented as biomarkers or therapeutic targets for NDs.
As such, the predicted metabolic genes may be of use as novel biomarkers not only for ND diagnosis but also for potential therapeutic treatments.
American Psychological Association (APA)
Ni, Qi& Su, Xianming& Chen, Jingqi& Tian, Weidong. 2015. Prediction of Metabolic Gene Biomarkers for Neurodegenerative Disease by an Integrated Network-Based Approach. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055468
Modern Language Association (MLA)
Ni, Qi…[et al.]. Prediction of Metabolic Gene Biomarkers for Neurodegenerative Disease by an Integrated Network-Based Approach. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055468
American Medical Association (AMA)
Ni, Qi& Su, Xianming& Chen, Jingqi& Tian, Weidong. Prediction of Metabolic Gene Biomarkers for Neurodegenerative Disease by an Integrated Network-Based Approach. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055468