Intratumoral Heterogeneity of MAGE-C1CT7 and MAGE-C2CT10 Expression in Mucosal Melanoma
Joint Authors
Holzmann, D.
Calvieri, Stefano
Curioni-Fontecedro, A.
Pitocco, R.
Schoenewolf, N. L.
Soldini, D.
Dummer, R.
Moch, H.
Mihic-Probst, D.
Fitsche, A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Mucosal melanoma is a rare disease, which differs from its cutaneous counterpart genetically and for its clinical behaviour.
Moreover this is a heterogeneous disease based on the tissue of origin.
As CT7 and CT10 are highly expressed in cutaneous melanoma and are immunogenic in this disease, we analysed their expression throughout the different subtypes of mucosal melanoma and tumor development.
We detected a frequent expression of CT7 in primaries and corresponding metastases (55%) as well as for CT10 (30%).
This expression resulted to be heterogeneous in the same tumor specimen and moreover influenced by the tissue of origin.
Our results support the role of these antigens in immunotherapy for mucosal melanoma.
American Psychological Association (APA)
Curioni-Fontecedro, A.& Pitocco, R.& Schoenewolf, N. L.& Holzmann, D.& Soldini, D.& Dummer, R.…[et al.]. 2015. Intratumoral Heterogeneity of MAGE-C1CT7 and MAGE-C2CT10 Expression in Mucosal Melanoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055469
Modern Language Association (MLA)
Curioni-Fontecedro, A.…[et al.]. Intratumoral Heterogeneity of MAGE-C1CT7 and MAGE-C2CT10 Expression in Mucosal Melanoma. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1055469
American Medical Association (AMA)
Curioni-Fontecedro, A.& Pitocco, R.& Schoenewolf, N. L.& Holzmann, D.& Soldini, D.& Dummer, R.…[et al.]. Intratumoral Heterogeneity of MAGE-C1CT7 and MAGE-C2CT10 Expression in Mucosal Melanoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055469