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Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Heart valve tissue-guided regeneration aims to offer a functional and viable alternative to current prosthetic replacements.
Not requiring previous cell seeding and conditioning in bioreactors, such exceptional tissue engineering approach is a very fascinating translational regenerative strategy.
After in vivo implantation, decellularized heart valve scaffolds drive their same repopulation by recipient’s cells for a prospective autologous-like tissue reconstruction, remodeling, and adaptation to the somatic growth of the patient.
With such a viability, tissue-guided regenerated conduits can be delivered as off-the-shelf biodevices and possess all the potentialities for a long-lasting resolution of the dramatic inconvenience of heart valve diseases, both in children and in the elderly.
A review on preclinical and clinical investigations of this therapeutic concept is provided with evaluation of the issues still to be well deliberated for an effective and safe in-human application.
American Psychological Association (APA)
Iop, Laura& Gerosa, Gino. 2015. Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055473
Modern Language Association (MLA)
Iop, Laura& Gerosa, Gino. Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055473
American Medical Association (AMA)
Iop, Laura& Gerosa, Gino. Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055473