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The Impact of Microgravity and Hypergravity on Endothelial Cells
Joint Authors
Monici, Monica
Maier, Jeanette A. M.
Cialdai, Francesca
Morbidelli, Lucia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The endothelial cells (ECs), which line the inner surface of vessels, play a fundamental role in maintaining vascular integrity and tissue homeostasis, since they regulate local blood flow and other physiological processes.
ECs are highly sensitive to mechanical stress, including hypergravity and microgravity.
Indeed, they undergo morphological and functional changes in response to alterations of gravity.
In particular microgravity leads to changes in the production and expression of vasoactive and inflammatory mediators and adhesion molecules, which mainly result from changes in the remodelling of the cytoskeleton and the distribution of caveolae.
These molecular modifications finely control cell survival, proliferation, apoptosis, migration, and angiogenesis.
This review summarizes the state of the art on how microgravity and hypergravity affect cultured ECs functions and discusses some controversial issues reported in the literature.
American Psychological Association (APA)
Maier, Jeanette A. M.& Cialdai, Francesca& Monici, Monica& Morbidelli, Lucia. 2015. The Impact of Microgravity and Hypergravity on Endothelial Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055477
Modern Language Association (MLA)
Maier, Jeanette A. M.…[et al.]. The Impact of Microgravity and Hypergravity on Endothelial Cells. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055477
American Medical Association (AMA)
Maier, Jeanette A. M.& Cialdai, Francesca& Monici, Monica& Morbidelli, Lucia. The Impact of Microgravity and Hypergravity on Endothelial Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055477