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The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NKT Cell Lymphoma, Nasal Type
Joint Authors
Liang, Li
Zhang, Zhang
Wang, Ying
Nong, Lin
Zheng, Yalin
Qu, Linlin
Zhang, Bo
Li, Ting
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
6q21 genetic deletion has been frequently detected in extranodal NK/T cell lymphoma, nasal type (EN-NK/T-NT), and PRDM1 is considered as candidate gene.
However, direct detection of PRDM1 deletion has not been well documented.
We investigated genetic alterations of 6q21 and PRDM1 in 43 cases of EN-NK/T-NT and cell lines by FISH.
PRDM1 expression was evaluated by immunohistochemistry and Western blot.
The correlation between genetic alteration and PRDM1 expression and the significance in clinic-pathologic were analyzed.
Heterozygous deletion of 6q21 and/or PRDM1 was observed in 24 of 43 cases (55.81%) of EN-NK/T-NT including 16 cases (37.21%) for 6q21 deletion and 19 cases (44.19%) for PRDM1 deletion.
Similarly, heterozygous codeletion of 6q21 and PRDM1 was identified in NK92 and NKL cells.
The heterozygous deletion of 6q21 and/or PRDM1 was correlated with PRDM1 expression.
However, genetic deletion of 6q21 and/or PRDM1 was not correlated with clinicopathological features of EN-NK/T-NT, while PRDM1 expression showed positive effect on the outcome of patients as those as disease site, B symptom, and clinical stage.
Thus, heterozygous deletion of 6q21 and/or PRDM1 was frequently detected in EN-NK/T-NT and correlated with downregulation of PRDM1.
But the prognostic role of genetic deletion needs to be further evaluated in larger cohort.
American Psychological Association (APA)
Liang, Li& Zhang, Zhang& Wang, Ying& Nong, Lin& Zheng, Yalin& Qu, Linlin…[et al.]. 2015. The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NKT Cell Lymphoma, Nasal Type. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055481
Modern Language Association (MLA)
Liang, Li…[et al.]. The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NKT Cell Lymphoma, Nasal Type. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055481
American Medical Association (AMA)
Liang, Li& Zhang, Zhang& Wang, Ying& Nong, Lin& Zheng, Yalin& Qu, Linlin…[et al.]. The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NKT Cell Lymphoma, Nasal Type. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055481