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Comparative Analysis of Apicoplast-Targeted Protein Extension Lengths in Apicomplexan Parasites
Joint Authors
Seliverstov, Alexander V.
Zverkov, Oleg A.
Istomina, Svetlana N.
Pirogov, Sergey A.
Kitsis, Philip S.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In general, the mechanism of protein translocation through the apicoplast membrane requires a specific extension of a functionally important region of the apicoplast-targeted proteins.
The corresponding signal peptides were detected in many apicomplexans but not in the majority of apicoplast-targeted proteins in Toxoplasma gondii.
In T.
gondii signal peptides are either much diverged or their extension region is processed, which in either case makes the situation different from other studied apicomplexans.
We propose a statistic method to compare extensions of the functionally important regions of apicoplast-targeted proteins.
More specifically, we provide a comparison of extension lengths of orthologous apicoplast-targeted proteins in apicomplexan parasites.
We focus on results obtained for the model species T.
gondii, Neospora caninum, and Plasmodium falciparum.
With our method, cross species comparisons demonstrate that, in average, apicoplast-targeted protein extensions in T.
gondii are 1.5-fold longer than in N.
caninum and 2-fold longer than in P.
falciparum.
Extensions in P.
falciparum less than 87 residues in size are longer than the corresponding extensions in N.
caninum and, reversely, are shorter if they exceed 88 residues.
American Psychological Association (APA)
Seliverstov, Alexander V.& Zverkov, Oleg A.& Istomina, Svetlana N.& Pirogov, Sergey A.& Kitsis, Philip S.. 2015. Comparative Analysis of Apicoplast-Targeted Protein Extension Lengths in Apicomplexan Parasites. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055514
Modern Language Association (MLA)
Seliverstov, Alexander V.…[et al.]. Comparative Analysis of Apicoplast-Targeted Protein Extension Lengths in Apicomplexan Parasites. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055514
American Medical Association (AMA)
Seliverstov, Alexander V.& Zverkov, Oleg A.& Istomina, Svetlana N.& Pirogov, Sergey A.& Kitsis, Philip S.. Comparative Analysis of Apicoplast-Targeted Protein Extension Lengths in Apicomplexan Parasites. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055514