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Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration
Joint Authors
Pavao, Mauro S. G.
Stelling, Mariana P.
Soares, Mariana A.
Teixeira, Felipe C. O. B.
Fontes, Miguel
Arêas, Ana Lúcia
Leal, Marcelo G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The metastatic disease is one of the main consequences of tumor progression, being responsible for most cancer-related deaths worldwide.
This review intends to present and discuss data on the relationship between integrins and heparan sulfate proteoglycans in health and cancer progression.
Integrins are a family of cell surface transmembrane receptors, responsible for cell-matrix and cell-cell adhesion.
Integrins’ main functions include cell adhesion, migration, and survival.
Heparan sulfate proteoglycans (HSPGs) are cell surface molecules that play important roles as cell receptors, cofactors, and overall direct or indirect contributors to cell organization.
Both molecules can act in conjunction to modulate cell behavior and affect malignancy.
In this review, we will discuss the different contexts in which various integrins, such as α5, αV, β1, and β3, interact with HSPGs species, such as syndecans and perlecans, affecting tissue homeostasis.
American Psychological Association (APA)
Soares, Mariana A.& Teixeira, Felipe C. O. B.& Fontes, Miguel& Arêas, Ana Lúcia& Leal, Marcelo G.& Pavao, Mauro S. G.…[et al.]. 2015. Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055521
Modern Language Association (MLA)
Soares, Mariana A.…[et al.]. Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055521
American Medical Association (AMA)
Soares, Mariana A.& Teixeira, Felipe C. O. B.& Fontes, Miguel& Arêas, Ana Lúcia& Leal, Marcelo G.& Pavao, Mauro S. G.…[et al.]. Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055521