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Targeting Cellular Metabolism Chemosensitizes the Doxorubicin-Resistant Human Breast Adenocarcinoma Cells
Joint Authors
Ma, Shulan
Jia, Rongfei
Li, Dongju
Shen, Bo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Metabolic energy preferentially produced by glycolysis was an advantageous metabolic phenotype of cancer cells.
It is also an essential contributor to the progression of multidrug resistance in cancer cells.
By developing human breast cancer MCF-7 cells resistant to doxorubicin (DOX) (MCF-7/MDR cells), the effects and mechanisms of 2-deoxy-D-glucose (2DG), a glucose analogue, on reversing multidrug resistance were investigated.
2DG significantly inhibited the viability of MCF-7/MDR cells and enhanced DOX-induced apoptosis by upregulating protein expression of AMPKα, P53, and caspase-3.
The study demonstrated that energy restriction induced by 2DG was relevant to the synergistic effect of 2DG and DOX.
The proteins of multidrug gene (the MDR-related protein, MRP1) and P-glycoprotein (P-gp) in MCF-7/MDR cells were downregulated after exposure to 2DG, accompanied with the suppression of the activity of ATP-dependent drug-efflux pump and transmembrane transporter, increasing the intracellular accumulation of DOX to reverse the chemoresistance in multidrug cancer cells.
American Psychological Association (APA)
Ma, Shulan& Jia, Rongfei& Li, Dongju& Shen, Bo. 2015. Targeting Cellular Metabolism Chemosensitizes the Doxorubicin-Resistant Human Breast Adenocarcinoma Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055526
Modern Language Association (MLA)
Ma, Shulan…[et al.]. Targeting Cellular Metabolism Chemosensitizes the Doxorubicin-Resistant Human Breast Adenocarcinoma Cells. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055526
American Medical Association (AMA)
Ma, Shulan& Jia, Rongfei& Li, Dongju& Shen, Bo. Targeting Cellular Metabolism Chemosensitizes the Doxorubicin-Resistant Human Breast Adenocarcinoma Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055526