Simultaneous Parameters Identifiability and Estimation of an E. coli Metabolic Network Model
Joint Authors
Pontes Freitas Alberton, Kese
Alberton, André Luís
Di Maggio, Jimena Andrea
Estrada, Vanina Gisela
Díaz, María Soledad
Secchi, Argimiro Resende
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-06
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
This work proposes a procedure for simultaneous parameters identifiability and estimation in metabolic networks in order to overcome difficulties associated with lack of experimental data and large number of parameters, a common scenario in the modeling of such systems.
As case study, the complex real problem of parameters identifiability of the Escherichia coli K-12 W3110 dynamic model was investigated, composed by 18 differential ordinary equations and 35 kinetic rates, containing 125 parameters.
With the procedure, model fit was improved for most of the measured metabolites, achieving 58 parameters estimated, including 5 unknown initial conditions.
The results indicate that simultaneous parameters identifiability and estimation approach in metabolic networks is appealing, since model fit to the most of measured metabolites was possible even when important measures of intracellular metabolites and good initial estimates of parameters are not available.
American Psychological Association (APA)
Pontes Freitas Alberton, Kese& Alberton, André Luís& Di Maggio, Jimena Andrea& Estrada, Vanina Gisela& Díaz, María Soledad& Secchi, Argimiro Resende. 2015. Simultaneous Parameters Identifiability and Estimation of an E. coli Metabolic Network Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1055530
Modern Language Association (MLA)
Pontes Freitas Alberton, Kese…[et al.]. Simultaneous Parameters Identifiability and Estimation of an E. coli Metabolic Network Model. BioMed Research International No. 2015 (2015), pp.1-21.
https://search.emarefa.net/detail/BIM-1055530
American Medical Association (AMA)
Pontes Freitas Alberton, Kese& Alberton, André Luís& Di Maggio, Jimena Andrea& Estrada, Vanina Gisela& Díaz, María Soledad& Secchi, Argimiro Resende. Simultaneous Parameters Identifiability and Estimation of an E. coli Metabolic Network Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1055530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055530