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Effect of Tyrosol and Farnesol on Virulence and Antibiotic Resistance of Clinical Isolates of Pseudomonas aeruginosa
Joint Authors
Hassan Abdel-Rhman, Shaymaa
Mostafa El-Mahdy, Areej
El-Mowafy, Mohammed
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Mixed-species biofilms could create a protected environment that allows for survival to external antimicrobials and allows different bacterial-fungal interactions.
Pseudomonas aeruginosa-Candida albicans coexistence is an example for such mixed-species community.
Numerous reports demonstrated how P.
aeruginosa or its metabolites could influence the growth, morphogenesis, and virulence of C.
albicans.
In this study, we investigated how the C.
albicans quorum sensing compounds, tyrosol and farnesol, might affect Egyptian clinical isolates of P.
aeruginosa regarding growth, antibiotic sensitivity, and virulence.
We could demonstrate that tyrosol possesses an antibacterial activity against P.
aeruginosa (10 µM inhibited more than 50% of growth after 16 h cultivation).
Moreover, we could show for the first time that tyrosol strongly inhibits the production of the virulence factors hemolysin and protease in P.
aeruginosa, whereas farnesol inhibits, to lower extent, hemolysin production in this bacterial pathogen.
Cumulatively, tyrosol is expected to strongly affect P.
aeruginosa in mixed microbial biofilm.
American Psychological Association (APA)
Hassan Abdel-Rhman, Shaymaa& Mostafa El-Mahdy, Areej& El-Mowafy, Mohammed. 2015. Effect of Tyrosol and Farnesol on Virulence and Antibiotic Resistance of Clinical Isolates of Pseudomonas aeruginosa. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055535
Modern Language Association (MLA)
Hassan Abdel-Rhman, Shaymaa…[et al.]. Effect of Tyrosol and Farnesol on Virulence and Antibiotic Resistance of Clinical Isolates of Pseudomonas aeruginosa. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055535
American Medical Association (AMA)
Hassan Abdel-Rhman, Shaymaa& Mostafa El-Mahdy, Areej& El-Mowafy, Mohammed. Effect of Tyrosol and Farnesol on Virulence and Antibiotic Resistance of Clinical Isolates of Pseudomonas aeruginosa. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055535