Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm
Joint Authors
Duerr, Georg D.
Dewald, Oliver
Gestrich, Christopher
Heinemann, Jan C.
Meertz, Anne
Probst, Chris
Roell, Wilhelm
Schiller, Wolfgang
Zimmer, Andreas
Bindila, Laura
Lutz, Beat
Welz, Armin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Human aortic aneurysms have been associated with inflammation and vascular remodeling.
Since the endocannabinoid system modulates inflammation and tissue remodeling, we investigated its components in human aortic aneurysms.
We obtained anterior aortic wall samples from patients undergoing elective surgery for aortic aneurysm or coronary artery disease as controls.
Histological and molecular analysis (RT-qPCR) was performed, and endocannabinoid concentration was determined using LC-MRM.
Patient characteristics were comparable between the groups except for a higher incidence of arterial hypertension and diabetes in the control group.
mRNA level of cannabinoid receptors was significantly higher in aneurysms than in controls.
Concentration of the endocannabinoid 2-arachidonoylglycerol was significantly higher, while the second endocannabinoid anandamide and its metabolite arachidonic acid and palmitoylethanolamide were significantly lower in aneurysms.
Histology revealed persistent infiltration of newly recruited leukocytes and significantly higher mononuclear cell density in adventitia of the aneurysms.
Proinflammatory environment in aneurysms was shown by significant upregulation of M-CSF and PPARγ but associated with downregulation of chemokines.
We found comparable collagen-stained area between the groups, significantly decreased mRNA level of CTGF, osteopontin-1, and MMP-2, and increased TIMP-4 expression in aneurysms.
Our data provides evidence for endocannabinoid system activation in human aortic aneurysms, associated with persistent low-level inflammation and vascular remodeling.
American Psychological Association (APA)
Gestrich, Christopher& Duerr, Georg D.& Heinemann, Jan C.& Meertz, Anne& Probst, Chris& Roell, Wilhelm…[et al.]. 2015. Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055537
Modern Language Association (MLA)
Gestrich, Christopher…[et al.]. Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055537
American Medical Association (AMA)
Gestrich, Christopher& Duerr, Georg D.& Heinemann, Jan C.& Meertz, Anne& Probst, Chris& Roell, Wilhelm…[et al.]. Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055537