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Growth Inhibition and Membrane Permeabilization of Candida lusitaniae Using Varied Pulse Shape Electroporation
Joint Authors
Novickij, V.
Grainys, A.
Lastauskienė, E.
Kananavičiūtė, R.
Pamedytytė, D.
Zinkevičienė, A.
Kalėdienė, L.
Novickij, J.
Paškevičius, A.
Švedienė, J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Candida lusitaniae is an opportunistic yeast pathogen, which can readily develop resistance to antifungal compounds and result in a complex long-term treatment.
The efficient treatment is difficult since structure and metabolic properties of the fungal cells are similar to those of eukaryotic host.
One of the potential methods to improve the inhibition rate or the cell permeability to inhibitors is the application of electroporation.
In this work we investigated the dynamics of the growth inhibition and membrane permeabilization of C.
lusitaniae by utilizing the various pulse shape and duration electric field pulses.
Our results indicated that single electroporation procedure using 8 kV/cm electric field may result in up to 51±5% inhibition rate.
Also it has been experimentally shown that the electroporation pulse shape may influence the inhibitory effect; however, the amplitude of the electric field and the pulse energy remain the most important parameters for definition of the treatment outcome.
The dynamics of the cell membrane permeabilization in the 2–8 kV/cm electric field were overviewed.
American Psychological Association (APA)
Novickij, V.& Grainys, A. & Lastauskienė, E. & Kananavičiūtė, R.& Pamedytytė, D.& Zinkevičienė, A.…[et al.]. 2015. Growth Inhibition and Membrane Permeabilization of Candida lusitaniae Using Varied Pulse Shape Electroporation. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055546
Modern Language Association (MLA)
Novickij, V.…[et al.]. Growth Inhibition and Membrane Permeabilization of Candida lusitaniae Using Varied Pulse Shape Electroporation. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055546
American Medical Association (AMA)
Novickij, V.& Grainys, A. & Lastauskienė, E. & Kananavičiūtė, R.& Pamedytytė, D.& Zinkevičienė, A.…[et al.]. Growth Inhibition and Membrane Permeabilization of Candida lusitaniae Using Varied Pulse Shape Electroporation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055546