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Synergistic Activity of Carfilzomib and Panobinostat in Multiple Myeloma Cells via Modulation of ROS Generation and ERK12
Joint Authors
Gao, Lu
Gao, Minjie
Yang, Guang
Tao, Yi
Kong, Yuanyuan
Yang, Ruixue
Meng, Xiuqin
Ai, Gongwen
Wei, Rong
Wu, Huiqun
Wu, Xiaosong
Shi, Jumei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Relapse of disease and subsequent resistance to established therapies remain as major challenges in the treatment of multiple myeloma (MM).
New therapeutic options are needed for these extensively pretreated patients.
To explore an optimized combinational therapy, interactions between the irreversible proteasome inhibitor carfilzomib exhibiting a well-tolerated side-effect profile and histone deacetylase inhibitor (HDACi) panobinostat (LBH589) were examined in MM cells.
Coadministration of carfilzomib and LBH589 led to a synergistic inhibition of proliferation in MM cells.
Further studies showed that the combined treatment synergistically increased mitochondrial injury, caspase activation, and apoptosis in MM cells.
Lethality of the carfilzomib/LBH589 combination was associated with the reactive oxygen species (ROS) generation and ERK1/2 inactivation.
In addition, the free radical scavenger N-acetylcysteine (NAC) could block carfilzomib and LBH589-induced oxidative stress and the subsequent apoptosis.
Together, these findings argue that the strategy of combining carfilzomib and LBH589 warrants attention in MM.
American Psychological Association (APA)
Gao, Lu& Gao, Minjie& Yang, Guang& Tao, Yi& Kong, Yuanyuan& Yang, Ruixue…[et al.]. 2015. Synergistic Activity of Carfilzomib and Panobinostat in Multiple Myeloma Cells via Modulation of ROS Generation and ERK12. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055551
Modern Language Association (MLA)
Gao, Lu…[et al.]. Synergistic Activity of Carfilzomib and Panobinostat in Multiple Myeloma Cells via Modulation of ROS Generation and ERK12. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055551
American Medical Association (AMA)
Gao, Lu& Gao, Minjie& Yang, Guang& Tao, Yi& Kong, Yuanyuan& Yang, Ruixue…[et al.]. Synergistic Activity of Carfilzomib and Panobinostat in Multiple Myeloma Cells via Modulation of ROS Generation and ERK12. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055551