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Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis
Joint Authors
Romeo, Stefano
Dongiovanni, Paola
Valenti, Luca
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Liver fat accumulation generally related to systemic insulin resistance characterizes nonalcoholic fatty liver disease (NAFLD), which in the presence of nonalcoholic steatohepatitis (NASH) can progress towards cirrhosis and hepatocellular carcinoma.
Due to the epidemic of obesity, NAFLD is now the most frequent liver disease in Western countries.
Epidemiological, familial, and twin studies provide evidence for a strong genetic component of NAFLD susceptibility.
Recently, genome-wide association studies led to the identification of the major inherited determinants of hepatic fat accumulation: patatin-like phospholipase domain-containing 3 (PNPLA3) I148M gene and transmembrane 6 superfamily member 2 (TM6SF2) E167K gene variants, involved in lipid droplets remodelling and very low-density lipoproteins secretion, are the major determinants of interindividual differences in liver steatosis, and susceptibility to progressive NASH.
In this review, we aimed to provide an overview of recent insights into the genetics of hepatic fat accumulation and steatohepatitis.
American Psychological Association (APA)
Dongiovanni, Paola& Romeo, Stefano& Valenti, Luca. 2015. Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055557
Modern Language Association (MLA)
Dongiovanni, Paola…[et al.]. Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055557
American Medical Association (AMA)
Dongiovanni, Paola& Romeo, Stefano& Valenti, Luca. Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055557