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Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis
Joint Authors
Lei, Du
Ma, Jun
Zhang, Jilei
Wang, Mengxing
Zhang, Kaihua
Chen, Fuqin
Suo, Xueling
Gong, Qiyong
Du, Xiaoxia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Primary monosymptomatic nocturnal enuresis (PMNE) is a common developmental disorder in children.
Previous literature has suggested that PMNE not only is a micturition disorder but also is characterized by cerebral structure abnormalities and dysfunction.
However, the biological mechanisms underlying the disease are not thoroughly understood.
Graph theoretical analysis has provided a unique tool to reveal the intrinsic attributes of the connectivity patterns of a complex network from a global perspective.
Resting-state fMRI was performed in 20 children with PMNE and 20 healthy controls.
Brain networks were constructed by computing Pearson’s correlations for blood oxygenation level-dependent temporal fluctuations among the 2 groups, followed by graph-based network analyses.
The functional brain networks in the PMNE patients were characterized by a significantly lower clustering coefficient, global and local efficiency, and higher characteristic path length compared with controls.
PMNE patients also showed a reduced nodal efficiency in the bilateral calcarine sulcus, bilateral cuneus, bilateral lingual gyri, and right superior temporal gyrus.
Our findings suggest that PMNE includes brain network alterations that may affect global communication and integration.
American Psychological Association (APA)
Lei, Du& Ma, Jun& Zhang, Jilei& Wang, Mengxing& Zhang, Kaihua& Chen, Fuqin…[et al.]. 2015. Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055575
Modern Language Association (MLA)
Lei, Du…[et al.]. Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055575
American Medical Association (AMA)
Lei, Du& Ma, Jun& Zhang, Jilei& Wang, Mengxing& Zhang, Kaihua& Chen, Fuqin…[et al.]. Connectome-Scale Assessments of Functional Connectivity in Children with Primary Monosymptomatic Nocturnal Enuresis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055575