Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis
Joint Authors
Brown, Tashalee R.
Krogh-Madsen, Trine
Christini, David J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The adult heart is composed of a dense network of cardiomyocytes surrounded by nonmyocytes, the mostabundant of which are cardiac fibroblasts.
Several cardiac diseases, such as myocardial infarction or dilatedcardiomyopathy, are associated with an increased density of fibroblasts, that is, fibrosis.
Fibroblasts play asignificant role in the development of electrical and mechanical dysfunction of the heart; however the underlyingmechanisms are only partially understood.
One widely studied mechanism suggests that fibroblasts produceexcess extracellular matrix, resulting in collagenous septa.
These collagenous septa slow propagation, causezig-zag conduction paths, and decouple cardiomyocytes resulting in a substrate for arrhythmia.
Anotheremerging mechanism suggests that fibroblasts promote arrhythmogenesis through direct electrical interactionswith cardiomyocytes via gap junctions.
Due to the challenges of investigating fibroblast-myocyte coupling innative cardiac tissue, computational modeling and in vitro experiments have facilitated the investigation into themechanisms underlying fibroblast-mediated changes in cardiomyocyte action potential morphology, conductionvelocity, spontaneous excitability, and vulnerability to reentry.
In this paper, we summarize the major findings ofthe existing computational studies investigating the implications of fibroblast-myocyte interactions in the normaland diseased heart.
We then present investigations from our group into the potential role of voltage-dependentgap junctions in fibroblast-myocyte interactions.
American Psychological Association (APA)
Brown, Tashalee R.& Krogh-Madsen, Trine& Christini, David J.. 2015. Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055585
Modern Language Association (MLA)
Brown, Tashalee R.…[et al.]. Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055585
American Medical Association (AMA)
Brown, Tashalee R.& Krogh-Madsen, Trine& Christini, David J.. Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055585