Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure
Joint Authors
Andrade, David C.
Lucero, Claudia
Toledo, Camilo
Madrid, Carlos
Marcus, Noah J.
Schultz, Harold D.
Del Rio, Rodrigo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Chronic heart failure (CHF) is a global health problem affecting millions of people.
Autonomic dysfunction and disordered breathing patterns are commonly observed in patients with CHF, and both are strongly related to poor prognosis and high mortality risk.
Tonic activation of carotid body (CB) chemoreceptors contributes to sympathoexcitation and disordered breathing patterns in experimental models of CHF.
Recent studies show that ablation of the CB chemoreceptors improves autonomic function and breathing control in CHF and improves survival.
These exciting findings indicate that alterations in CB function are critical to the progression of CHF.
Therefore, better understanding of the physiology of the CB chemoreflex in CHF could lead to improvements in current treatments and clinical management of patients with CHF characterized by high chemosensitivity.
Accordingly, the main focus of this brief review is to summarize current knowledge of CB chemoreflex function in different experimental models of CHF and to comment on their potential translation to treatment of human CHF.
American Psychological Association (APA)
Andrade, David C.& Lucero, Claudia& Toledo, Camilo& Madrid, Carlos& Marcus, Noah J.& Schultz, Harold D.…[et al.]. 2015. Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055589
Modern Language Association (MLA)
Andrade, David C.…[et al.]. Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055589
American Medical Association (AMA)
Andrade, David C.& Lucero, Claudia& Toledo, Camilo& Madrid, Carlos& Marcus, Noah J.& Schultz, Harold D.…[et al.]. Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055589