Ultrafast Cone-Beam Computed Tomography: A Comparative Study of Imaging Protocols during Image-Guided Therapy Procedure

Abstract EN

Objective.

To evaluate two ultrafast cone-beam CT (UF-CBCT) imaging protocols with different acquisition and injection parameters regarding image quality and required contrast media during image-guided hepatic transarterial chemoembolization (TACE).

Methods.

In 80 patients (male: 46, female: 34; mean age: 56.8 years; range: 33–83) UF-CBCT was performed during TACE for intraprocedural guidance.

Imaging was performed using two ultrafast CBCT acquisition protocols with different acquisition and injection parameters (imaging protocol 1: acquisition time 2.54 s, and contrast 6 mL with 3 s delay; imaging protocol 2: acquisition time 2.72 s, and contrast 7 mL with 6 s delay).

Image evaluation was performed with both qualitative and quantitative methods.

Contrast injection volume and dose parameters were compared using values from the literature.

Results.

Imaging protocol 2 provided significantly better ( P < 0.05 ) image quality than protocol 1 at the cost of slightly higher contrast load and patient dose.

Imaging protocol 1 provided good contrast perfusion but it mostly failed to delineate the tumors ( P < 0.05 ) .

On the contrary, imaging protocol 2 showed excellent enhancement of hepatic parenchyma, tumor, and feeding vessels.

Conclusion.

Tumor delineation, visualization of hepatic parenchyma, and feeding vessels are clearly possible using imaging protocol 2 with ultrafast CBCT imaging.

A reduction of required contrast volume and patient dose were achieved due to the ultrafast CBCT imaging.