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Molecular Epidemiology of Human Norovirus in Korea in 2013
Joint Authors
Kim, Jae-Seok
Kim, Hyun Soo
Hyun, Jungwon
Kim, Han-Sung
Song, Wonkeun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Norovirus is a major cause of acute gastroenteritis.
The molecular epidemiology of norovirus exhibits temporal and geographical fluctuations, and new variants of the GII.4 genotype emerge every 2-3 years to cause global epidemics of acute gastroenteritis.
We investigated GI and GII genotypes of human norovirus strains isolated from patients with acute gastroenteritis in Korea in 2013.
Norovirus antigen test was performed on 2,980 fecal specimens from January to December 2013.
RNA was extracted from norovirus antigen-positive fecal suspensions, and the norovirus capsid (VP1) and polymerase (RdRp) genes were characterized by RT-PCR and sequencing.
Of the 230 genotyped strains, GII.4 (77.3%) was the most frequently observed capsid genotype, followed by GII.3 (6.1%) and GII.13 (3.9%).
A norovirus GII.4 variant, GII.Pe/GII.4 Sydney 2012, was the most frequently found polymerase/capsid genotype (65.7%), followed by GII.P17/GII.17 (2.1%) and GII.P21/GII.3 (2.1%).
Phylogenetic, similarity, and capsid epitope analyses of GII.Pe/GII.4 Sydney 2012 strains were performed.
We concluded that the norovirus GII.4 variant, GII.Pe/GII.4 Sydney 2012, was the main cause of norovirus-related gastroenteritis in Korea in 2013.
American Psychological Association (APA)
Kim, Jae-Seok& Kim, Hyun Soo& Hyun, Jungwon& Kim, Han-Sung& Song, Wonkeun. 2015. Molecular Epidemiology of Human Norovirus in Korea in 2013. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055592
Modern Language Association (MLA)
Kim, Jae-Seok…[et al.]. Molecular Epidemiology of Human Norovirus in Korea in 2013. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055592
American Medical Association (AMA)
Kim, Jae-Seok& Kim, Hyun Soo& Hyun, Jungwon& Kim, Han-Sung& Song, Wonkeun. Molecular Epidemiology of Human Norovirus in Korea in 2013. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055592