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Vitamin D and Inflammatory Bowel Disease
Joint Authors
Ardesia, Marco
Ferlazzo, Guido
Fries, Walter
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Vitamin D deficiency has been recognized as an environmental risk factor for Crohn’s disease since the early 80s.
Initially, this finding was correlated with metabolic bone disease.
Low serum 25-hydroxyvitamin D levels have been repeatedly reported in inflammatory bowel diseases together with a relationship between vitamin D status and disease activity.
Subsequently, low serum vitamin D levels have been reported in various immune-related diseases pointing to an immunoregulatory role.
Indeed, vitamin D and its receptor (VDR) are known to interact with different players of the immune homeostasis by controlling cell proliferation, antigen receptor signalling, and intestinal barrier function.
Moreover, 1,25-dihydroxyvitamin D is implicated in NOD2-mediated expression of defensin-β2, the latter known to play a crucial role in the pathogenesis of Crohn’s disease (IBD1 gene), and several genetic variants of the vitamin D receptor have been identified as Crohn’s disease candidate susceptibility genes.
From animal models we have learned that deletion of the VDR gene was associated with a more severe disease.
There is a growing body of evidence concerning the therapeutic role of vitamin D/synthetic vitamin D receptor agonists in clinical and experimental models of inflammatory bowel disease far beyond the role of calcium homeostasis and bone metabolism.
American Psychological Association (APA)
Ardesia, Marco& Ferlazzo, Guido& Fries, Walter. 2015. Vitamin D and Inflammatory Bowel Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1055602
Modern Language Association (MLA)
Ardesia, Marco…[et al.]. Vitamin D and Inflammatory Bowel Disease. BioMed Research International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1055602
American Medical Association (AMA)
Ardesia, Marco& Ferlazzo, Guido& Fries, Walter. Vitamin D and Inflammatory Bowel Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1055602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055602