Influence of Intra-Articular Administration of Trichostatin A on Autologous Osteochondral Transplantation in a Rabbit Model
Joint Authors
Teng, Huajian
Hou, Huacheng
Zheng, Ke
Wang, Guanghu
Ikegawa, Shiro
Gao, Xiang
Qin, Jinzhong
Jiang, Qing
Zheng, Ming Hao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Autologous osteochondral transplantation (AOT) is a method for articular cartilage repair.
However, several disadvantages of this method have been reported, such as transplanted cartilage degeneration and the lack of a connection between the grafted and adjacent cartilage tissues.
To evaluate the effect of intra-articular administration of trichostatin A (TSA) on AOT, we conducted a case control study in a rabbit model.
International Cartilage Repair Society (ICRS) macroscopic scores, the modified O’Driscoll histology scores, and real-time PCR were utilized to evaluate the results.
At 4 weeks, both macroscopic and histological assessments showed that there was no significant difference between the TSA and control groups.
However, the mean macroscopic and histological scores for the TSA-treated group were significantly higher than the scores for the control group at 12 weeks.
TSA was shown to directly reduce collagen type II (COL2), aggrecan, matrix metalloproteinase (MMP), and a disintegrin and metalloproteinase domain with thrombospondin motifs 5 (ADAMTS-5) expression and to simultaneously repress the upregulation of MMP-3, MMP-9, and MMP-13 levels induced by interleukin 1β (IL-1β) in chondrocytes.
In conclusion, TSA protects AOT grafts from degeneration, which may provide a benefit in the repair of articular cartilage injury.
American Psychological Association (APA)
Hou, Huacheng& Zheng, Ke& Wang, Guanghu& Ikegawa, Shiro& Zheng, Ming Hao& Gao, Xiang…[et al.]. 2015. Influence of Intra-Articular Administration of Trichostatin A on Autologous Osteochondral Transplantation in a Rabbit Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055604
Modern Language Association (MLA)
Hou, Huacheng…[et al.]. Influence of Intra-Articular Administration of Trichostatin A on Autologous Osteochondral Transplantation in a Rabbit Model. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055604
American Medical Association (AMA)
Hou, Huacheng& Zheng, Ke& Wang, Guanghu& Ikegawa, Shiro& Zheng, Ming Hao& Gao, Xiang…[et al.]. Influence of Intra-Articular Administration of Trichostatin A on Autologous Osteochondral Transplantation in a Rabbit Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055604