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Near-Infrared Spectroscopy as a Diagnostic Tool for Distinguishing between Normal and Malignant Colorectal Tissues
Joint Authors
Chen, Hui
Lin, Zan
Wu, Tong
Tan, Chao
Mo, Lin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cancer diagnosis is one of the most important tasks of biomedical research and has become the main objective of medical investigations.
The present paper proposed an analytical strategy for distinguishing between normal and malignant colorectal tissues by combining the use of near-infrared (NIR) spectroscopy with chemometrics.
The successive projection algorithm-linear discriminant analysis (SPA-LDA) was used to seek a reduced subset of variables/wavenumbers and build a diagnostic model of LDA.
For comparison, the partial least squares-discriminant analysis (PLS-DA) based on full-spectrum classification was also used as the reference.
Principal component analysis (PCA) was used for a preliminary analysis.
A total of 186 spectra from 20 patients with partial colorectal resection were collected and divided into three subsets for training, optimizing, and testing the model.
The results showed that, compared to PLS-DA, SPA-LDA provided more parsimonious model using only three wavenumbers/variables (4065, 4173, and 5758 cm−1) to achieve the sensitivity of 84.6%, 92.3%, and 92.3% for the training, validation, and test sets, respectively, and the specificity of 100% for each subset.
It indicated that the combination of NIR spectroscopy and SPA-LDA algorithm can serve as a potential tool for distinguishing between normal and malignant colorectal tissues.
American Psychological Association (APA)
Chen, Hui& Lin, Zan& Mo, Lin& Wu, Tong& Tan, Chao. 2015. Near-Infrared Spectroscopy as a Diagnostic Tool for Distinguishing between Normal and Malignant Colorectal Tissues. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055608
Modern Language Association (MLA)
Chen, Hui…[et al.]. Near-Infrared Spectroscopy as a Diagnostic Tool for Distinguishing between Normal and Malignant Colorectal Tissues. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055608
American Medical Association (AMA)
Chen, Hui& Lin, Zan& Mo, Lin& Wu, Tong& Tan, Chao. Near-Infrared Spectroscopy as a Diagnostic Tool for Distinguishing between Normal and Malignant Colorectal Tissues. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055608