Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs
Joint Authors
Amicone, Laura
Citarella, Franca
Cicchini, Carla
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy.
Moreover, HCC onset and progression correlate with the deregulation of several long noncoding RNAs (lncRNAs), exhibiting great biological significance.
As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms.
Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development.
The evidence presented in this review highlights that lncRNAs-mediated epigenetic regulation should be taken into account for potential targeted therapeutic approaches.
American Psychological Association (APA)
Amicone, Laura& Citarella, Franca& Cicchini, Carla. 2015. Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055613
Modern Language Association (MLA)
Amicone, Laura…[et al.]. Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055613
American Medical Association (AMA)
Amicone, Laura& Citarella, Franca& Cicchini, Carla. Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055613