Microvessels Density in Uterine Leiomyosarcoma
Joint Authors
Bobiński, Marcin
Szumiło, Justyna
Cybulski, Marek
Kotarski, Jan
Polak, Grzegorz
Bednarek, Wiesława
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Uterine leiomyosarcomas (LMS) are rare tumors typically presenting rapid growth and unfavorable outcome.
Nowadays the results of uterine LMS treatment do not meet expectations.
Angiogenesis is one of processes investigated to be target for future treatment.
The aim of the research was to assess microvessels density (MVD) in tumor samples collected from 50 patients with histological confirmed uterine leiomyosarcoma and to investigate statistical relations between MVD, patients survival, and FIGO stage of tumor.
The assessment was carried out using immunohistochemistry methods with anti-CD34 antibody.
No significant difference in MVD between FIGO stages was observed.
Furthermore, contrary to many other malignancies, we found no significant relation between MVD and patients overall and 2-year survival.
Results obtained in the study suggest that processes on vascular mimicry and mesenchymal to epithelial transition (MET) may play important role in development of LMS.
No statistical relation between MVD and survival leads to conclusion that not only angiogenesis but other mechanisms as well should be taken into consideration in planning future research.
American Psychological Association (APA)
Bobiński, Marcin& Bednarek, Wiesława& Szumiło, Justyna& Cybulski, Marek& Polak, Grzegorz& Kotarski, Jan. 2015. Microvessels Density in Uterine Leiomyosarcoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055616
Modern Language Association (MLA)
Bobiński, Marcin…[et al.]. Microvessels Density in Uterine Leiomyosarcoma. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1055616
American Medical Association (AMA)
Bobiński, Marcin& Bednarek, Wiesława& Szumiło, Justyna& Cybulski, Marek& Polak, Grzegorz& Kotarski, Jan. Microvessels Density in Uterine Leiomyosarcoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055616