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SLC4A11 and the Pathophysiology of Congenital Hereditary Endothelial Dystrophy
Joint Authors
Patel, Sangita P.
Parker, Mark D.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Congenital hereditary endothelial dystrophy (CHED) is a rare autosomal recessive disorder of the corneal endothelium characterized by nonprogressive bilateral corneal edema and opacification present at birth.
Here we review the current knowledge on the role of the SLC4A11 gene, protein, and its mutations in the pathophysiology and clinical presentation of CHED.
Individuals with CHED have mutations in SLC4A11 which encodes a transmembrane protein in the SLC4 family of bicarbonate transporters.
The expression of SLC4A11 in the corneal endothelium and inner ear patterns the deficits seen in CHED with corneal edema and hearing loss (Harboyan syndrome).
slc4a11-null-mouse models recapitulate the CHED disease phenotype, thus establishing a functional role for SLC4A11 in CHED.
However, the transport function of SLC4A11 remains unsettled.
Some of the roles that have been attributed to SLC4A11 include H+ and NH 4 + permeation, electrogenic Na+-H+ exchange, and water transport.
Future studies of the consequences of SLC4A11 dysfunction as well as further understanding of corneal endothelial ion transport will help clarify the involvement of SLC4A11 in the pathophysiology of CHED.
American Psychological Association (APA)
Patel, Sangita P.& Parker, Mark D.. 2015. SLC4A11 and the Pathophysiology of Congenital Hereditary Endothelial Dystrophy. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055618
Modern Language Association (MLA)
Patel, Sangita P.& Parker, Mark D.. SLC4A11 and the Pathophysiology of Congenital Hereditary Endothelial Dystrophy. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055618
American Medical Association (AMA)
Patel, Sangita P.& Parker, Mark D.. SLC4A11 and the Pathophysiology of Congenital Hereditary Endothelial Dystrophy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055618